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| First Name: | Zaven | | Last Name: | Khachaturian | | Title: | Consultant: Alzheimer/Aging | | Advanced Degrees: | PhD | | Affiliation: | Khachaturian, Radebaugh & Associates (KRA), Inc. | | Street Address 1: | 8912 Copenhaver Dr. | | City: | Potomac | | State/Province: | MD | | Zip/Postal Code: | 20854 | Country/Territory: | U.S.A. | | Phone: | 301 294 7201 | | Fax: | 301-293-7203 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 10 February 2004]
We KRA, Inc., have consulting agreements with the Alzheimer’s Association, Toyama Chemical Co. (Japan), and GSK.
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View all comments by Zaven Khachaturian
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Aging Process, Stroke and Trauma, Alzheimer Disease, Tauopathies
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Proteomics, Signal transduction, Apoptosis/Cell cycle, Genetics, memory/cognition, Molecular and Cell biology, Electrophysiology, Tau/Cytoskeleton, Neuropathology, Diagnosis, Epidemiology, Neurobiology, Brain imaging, Animal Models, Chemistry/Pharmacology, Clinical trials, Oxidative Stress, Protein structure/chemistry
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Research institute, Foundations, University, Medical hospital, Industry
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Zaven Khachaturian is a consultant, lecturer and an author. He is the former Director, Office of Alzheimer’s Disease Research - National Institutes of Health (NIH), and the former Associate Director, Neuroscience and Neuropsychology of Aging Program (NNA) - National Institution on Aging (NIA), NIH.
During his tenure at the NIH he played a key role in planning, developing and administering many of the, now well established, national programs of research on Alzheimer’s disease and brain aging. He is generally recognized as the godfather of neurobiology of aging research and the chief architect of the Alzheimer’s disease research programs supported by the U.S. Government. He was responsible for building national infrastructure for clinical research. While serving as a program developer and director at NIA, he recruited many new investigators to the field and served as a mentor; in the early careers of numerous current opinion leaders in Alzheimer’s disease and neurobiology of aging research.
Now, as a consultant he provides guidance to universities, foundations, pharmaceutical and biotechnology companies, and nursing homes in program evaluation, planning, and development. He assists in formulating strategies for fund raising, media relations, marketing, and legislative initiatives. He maintains a full schedule as an author, translating science to lay consumers, and as a public speaker on such topics as: Aging, Alzheimer’s disease, Politics of Science, Prospects of Preventing Disabilities of Aging, Barriers to the Development of Effective Treatments, Revolutions in Models of Care and Future Trends in Research. He serves on the editorial boards of several publications and the advisory committees of many organizations. Currently he serves as Senior Medical and Scientific Advisor to the Alzheimer’s Association. He is a former member of the FDA Peripheral and Central Nervous System (PCNS) Advisory Committee and now he serves as an ad hoc consultant to that committee. |
Khachaturian, Z.S., 2002, “The Challenges of Developing & Validating Molecular & Biochemical Markers of Alzheimer’s Disease”.
Neurobiology of Aging 23 (4):509-512.
Khachaturian, Z.S., 2002, “Models and Modeling Systems in Alzheimer disease Drug Discovery”
Alzheimer Disease & Associated Disorders 2002; 16 Suppl. 1: S9-S12
Khachaturian, Z.S., 2000. “Epilogue: Toward a Comprehensive Theory of Alzheimer’s Disease – Challenges, Caveats and Parameters”.
In: Alzheimer’s Disease: A Compendium of Current Theories. Khachaturian, Z. S. &. Mesulam, M. M., Eds. Ann. NY Acad. Sci. 924: 184-193.
Khachaturian, Z. S., 1997. “Plundered Memories”. The Sciences (NY Acad. Sci.). 37 (4): 20-25. July/August 1997
Khachaturian, Z.S. and Radebaugh, T.S., Eds. 1996. Alzheimer’s Diseases: Cause(s), Diagnosis, Treatment, & Care. CRC Press, Boca Raton Fl.
Khachaturian, Z.S., 1995. “Alzheimer’s Disease: Progress Toward Untangling the Mystery”. In: Appel, S. (Ed.) Current Neurology. 15:193-210. Mosby, St Louis.
Khachaturian, Z.S., 1985. “Diagnosis of Alzheimer’s Disease”. Arch. Neurol.42: 1097-1105.
Khachaturian, Z.S., 1994 “Calcium Hypothesis of Alzheimer’s Disease and Brain Aging”. In Calcium Hypothesis Of Aging and Dementia. Disterhoft, J. F., Willem, H. G., Treber, J., Khachaturian, Z.S., Eds. Ann. N.Y. Acad. Sci. 747: 1-11.
Khachaturian, Z.S., 1994. “Scientific Opportunities for Developing Treatments for Alzheimer’s Disease”. In Future Directions in Alzheimer’s Disease Research: Proceedings of Research Planning Workshop I. Khachaturian, Z.S. (Guest Editor) Neurobiology of Aging (Supplement) 15 (2): 1-197. |
A comprehenisive theory and a testable conceptual model of rhe disease |
Multi-site longitudinal epidemiological study of putative risk factors (in large populations). |
AD is a multigenic disease i.e., several alternative etiologic factors (paths) lead to the disease; among these metabolic dysfunctions are a major contributing factor. |
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